/Characterization of a waveguide-based rapid biosensor platform

Characterization of a waveguide-based rapid biosensor platform

Master projects/internships - Leuven | More than two weeks ago

Evaluate tomorrow's rapid diagnostic biosensors

Within the Life Science Technologies department of imec, we develop the next generation of ‘lab-on-chip’ technologies that enable rapid disease diagnosis. In the last years, we developed an on-chip photonic waveguide platform that could potentially replace the traditional immunoassays testing. The working principle is based on the use of photonic waveguides for both the evanescent, fluorescent excitation and detection. This allows sensing close to the sensor surface without background interference enabling wash-free assays with kinetic readout. Using this technique, we already demonstrated quantification of biomarkers at the sub-picomolar level in clinically relevant samples. We have recently designed and fabricated a next generation of photonic waveguides and additional on-chip structures with improved properties.

The proposed master’s thesis topic focusses on the characterization of the performance of these improved photonic waveguides. The student will encounter a wide range of experimental techniques, including surface functionalization, assembly and testing of flow cells, improving data analysis pipelines, fluorescent labelling of proteins and on-chip as well as regular immuno assays.

We are looking for a highly motivated candidate that has an excellent knowledge of biochemistry, and a strong interest in nanotechnology. As the student will be working in a highly international environment, a good command of the English language (spoken and written) is recommended. Due to the topic's highly interdisciplinary nature, we strongly advise the student to discuss the project with the supervisors prior to their application.

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Type of project: Thesis

 

Duration: 1 year

Required degree: Master of Science

Required background: Nanoscience & Nanotechnology, Physics

Supervising scientist(s): For further information or for application, please contact: Kris Covens (Kris.Covens@imec.be)

Only for self-supporting students.