Nano-electrophoresis is expected to allow the detection of minute amounts of DNA (single-molecule analysis), leading the way to improved diagnostics and forensic sciences, among others. However, scaling down traditional electrophoretic techniques is hampered by current fabrication technologies, that do not deliver the required resolution and control. In this project the student will use IMEC nanofabrication capabilities to develop new designs for configurable 2D microchip electrophoresis in micro and nanoscale. The precise control resulting from it will allow more thorough analysis of complex samples. The structures will be fabricated using photolithography. The developed prototype will be compared with benchmark DNA analysis methods. The work will demand 20% time for electrical-fluidic Multiphysics, 70% lab work to fabricate and test the device and 10% for literature study and thesis writing. A multidisciplinary team at the Life Science Technology department at IMEC will support the thesis.
Skills to be learned: photolithography, microdevice metrology, capillary electrophoresis, biological sample preparation, fluorescence detection, COMSOL simulation.
Type of project: Thesis
Duration: 6-12 months
Required degree: Master of Engineering Technology, Master of Science, Master of Engineering Science, Master of Bioengineering
Required background: Biomedical engineering, Bioscience Engineering, Chemistry/Chemical Engineering, Electromechanical engineering, Electrotechnics/Electrical Engineering, Nanoscience & Nanotechnology, Physics
Supervising scientist(s): For further information or for application, please contact: Camila Dalben Madeira Campos (Camila.Campos@imec.be)
Only for self-supporting students