Development of a fluorescence activated droplet sorting with dielectrophoretic actuation

Leuven - Master projects/internships
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More than two weeks ago

New microdevice designs for more efficient separations of biological samples and enable single-cell analysis.

Single-cell analysis benefits areas as diverse as medicine and food industry, by guiding treatment of heterogeneous tumors or improving bio-processes. However, exploring its full potential requires developing sensitive detection and manipulation methods. Droplets microfluidics (digital fluidics) contribute to these efforts by allowing researchers to digitalize samples and analyze a large number of cells independently in a short-time.

The master's project will comprise the development of a droplet sorter activated by dielectrophoresis (DEP). Unlike the designs currently available in the literature, the DEP electrodes and the microfluidic structures will be fabricated in-situ by photolithography. This could lead to stronger DEP force with lower required electric potential, reducing risks to damage samples. It will allow higher throughput, decreasing analysis time and cost.

The work will demand 40% time for electrical-fluidic Multiphysics modelling in COMSOL, 50% for lab work for device fabrication and testing and 10% for literature study and thesis writing. A multidisciplinary team at the Life Science Technology department at imec will support the thesis.

Skills to be learned: photolithography, microdevice metrology, DEP, COMSOL simulation. 



Type of project: Thesis

Duration: 6-12 months

Required degree: Master of Engineering Technology, Master of Science, Master of Engineering Science, Master of Bioengineering

Required background: Biomedical engineering, Bioscience Engineering, Chemistry/Chemical Engineering, Electromechanical engineering, Electrotechnics/Electrical Engineering, Nanoscience & Nanotechnology, Physics

Supervising scientist(s): For further information or for application, please contact: Camila Dalben Madeira Campos (Camila.Campos@imec.be)

Only for self-supporting students

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