/Immune system on chip: immune cell interactions with tissue barriers on sensor integrated microfluidic chips

Immune system on chip: immune cell interactions with tissue barriers on sensor integrated microfluidic chips

PhD - Leuven | More than two weeks ago

Develop novel assays to study the immune system in vitro and its role in interaction with tissue barriers, using imec's organ-on-chip platforms

Microphysiological Systems (MPS) are microfluidic chips containing multiple cell types and aim to emulate a human organ in a specific context. This is particularly interesting for pre-clinical drug development, as today mostly animal models or simplified in vitro models are used. MPS are also powerful devices to emulate complex disease by using human cells in dynamic environments. The human immune system is a very complex interplay of cells and molecules and is very different from other species. Moreover, It is very challenging to study the immune system in vitro. Imec's MPS platform uses integrated electrodes to tissue barrier integrity, for example in the gut or the brain. This project will aim to investigate novel ways of quantifying interactions of the immune system with cellular barriers, using on-chip electrodes. The candidate will develop novel assays on imec's MPS platform and novel measurement techniques using impedance spectroscopy. 

 

Required background: Biomedical engineering, biomedical sciences or bioengineering

 

Type of work: 70% experimental, 20% data analysis, 10% literature

Supervisor: Liesbet Lagae

Co-supervisor: Dries Braeken

Daily advisor: Saeedeh Ebrahimi Takalloo

The reference code for this position is 2023-120. Mention this reference code on your application form.

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