/Low-latency extracellular spike sorting and network reconstruction of in-vitro neuronal networks

Low-latency extracellular spike sorting and network reconstruction of in-vitro neuronal networks

Leuven | More than two weeks ago

Help scientists understanding brain signals

In vitro cultured neuronal microcircuits are a highly interesting model system to investigate brain function and neurological disease states. These studies depend on state-of-the-art high-density CMOS multielectrode array (CMOS-MEA) technology to record electrophysiology signals from thousands of recording channels simultaneously using subcellular-sized electrodes. Electrophysiological signals recorded from these circuits provide distinctive information on the nature of the network and can be employed to unravel mechanisms of relevant neurodegenerative diseases.

Translation from the raw signals to biologically meaningful results is not straightforward and require advanced computing methods. Whereas most of these computations would be performed on external processing systems (GPU/CPU), the research would greatly benefit from on-site or edge computing capabilities. In this project the student will explore various field programmable gate array (FPGA)-based implementations of spike sorting algorithms to infer knowledge on synaptic connectivity between neuron pairs. This research into edge systems will omit the need for heavy data transmission and will reduce the processing latency enabling research into a new class of electrophysiological features.



Type of project: Thesis, Combination of internship and thesis

Duration: minimum 6 months

Required degree: Master of Engineering Technology, Master of Engineering Science, Master of Bioengineering, Master of Science

Required background: Biomedical engineering, Electrotechnics/Electrical Engineering, Computer Science, Bioscience Engineering

Supervising scientist(s): For further information or for application, please contact: Carolina Mora Lopez (Carolina.MoraLopez@imec.be) and Dennis Lambrechts (Dennis.Lambrechts@imec.be) and Beatriz Barros (Beatriz.Barros@imec.be)

Imec allowance will be provided for students studying at a non-Belgian university.

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