/Microfluidic scaffolds for organoid interfacing

Microfluidic scaffolds for organoid interfacing

PhD - Leuven | More than two weeks ago

Create new scaffolds to interface with organoids using imec’s microfluidic and cell interfacing technology expertise.

Organoids are three-dimensional cell cultures engineered from induced human pluripotent stem cells (iPSCs) to generate at least partial structures which mimic cellular and anatomical features of the human organ

This technology is gaining increasing momentum in biomedical research and drug development, such as brain organoids as new models for brain disease and intestine organoids for new drug development. Organoids also bear high potential as novel models in advancing personalized medicine as patient specific features can be implemented so human phenotypes can be created.

Current shortcomings of these models are the limited robustness and large variability due to lack of scaffolds and complete random organization of the cell structures, and the lack of vascularization causing non-uniformities and necrotic cores. Imec has developed combinatorial microfluidics and cell interfacing technology using advanced microfabrication methods, which will be combined here to tackle the organoid challenges. The candidate will develop new microfluidic and biosensor containing scaffolds based on imec’s neural interfacing technologies and characterize these structures by interfacing them with organoids. The candidate will be part of imec’s life sciences department and interact with specialists in microfabrication, cell culture, microfluidics and electrophysiology, and through collaborations with biomedical researchers and clinicians. 

 

Required background: Biomedical engineering or equivalent

 

Type of work: 20% modeling/simulation, 50% experimental, 20% fabrication, 10% literature

Supervisor: Liesbet Lagae

Co-supervisor: Dries Braeken

Daily advisor: Mar Condor

The reference code for this position is 2022-089. Mention this reference code on your application form.