CMOS and beyond CMOS
Discover why imec is the premier R&D center for advanced logic & memory devices. anced logic & memory devices.
Connected health solutions
Explore the technologies that will power tomorrow’s wearable, implantable, ingestible and non-contact devices.
Life sciences
See how imec brings the power of chip technology to the world of healthcare.
Sensor solutions for IoT
Dive into innovative solutions for sensor networks, high speed networks and sensor technologies.
Artificial intelligence
Explore the possibilities and technologies of AI.
More expertises
Discover all our expertises.
Be the first to reap the benefits of imec’s research by joining one of our programs or starting an exclusive bilateral collaboration.
Build on our expertise for the design, prototyping and low-volume manufacturing of your innovative nanotech components and products.
Use one of imec’s mature technologies for groundbreaking applications across a multitude of industries such as healthcare, agriculture and Industry 4.0.
Venturing and startups
Kick-start your business. Launch or expand your tech company by drawing on the funds and knowhow of imec’s ecosystem of tailored venturing support.
/Job opportunities/Modeling nanofluidic transport of single proteins through nanopores

Modeling nanofluidic transport of single proteins through nanopores

Research & development - Leuven | More than two weeks ago

Use state-of-the-art computational methods to help develop the single-molecule sensors of the future.

Over the past two decades, nanopores have been developed as highly sensitive sensors, capable of detecting and distinguishing individual molecules through the monitoring of the ionic current that flows through them [1]. Due to their broad applicability and inherent small size, nanopores are poised to enable personalized healthcare (e.g., affordable DNA sequencing and real-time biomarkers detection). As single-molecule sensors, they are also useful tools in the fundamental sciences, for example to investigate the kinetics of individual enzymes, or to improve our understanding of fluidic transport at the nanoscale.

In this thesis topic, the student will make use of computer simulations to investigate how the combined dynamics of ions, water molecules, and analyte molecules—all within the confinement of the nanoporeresults in the experimentally observed signal. At imec, we are performing state-of-the-art research on solid-state and biological nanopores using both experimental and simulation methodologies. The focus of this project will be two-fold

  1. to expand and improve the existing nanopore simulation methods, and

  2. to model the transport of individual proteins through these nanopores.

Hence, the successful candidate should be eager to learn about the physics of fluids and proteins but should also not be averse to solving partial differential equations (analytically or numerically). Preexisting knowledge is not required but experience with problem-solving using a programming language (Python, C++) would certainly be beneficial.


[1] Willems K., Computational modeling of biological nanopores, 2020 (Ph.D. dissertation)

Type of project: Thesis

Duration: 6 months

Required degree: Master of Engineering Science

Required background: Nanoscience & Nanotechnology

Supervising scientist(s): For further information or for application, please contact: Kherim Willems (

Only for self-supporting students.