/Multi-physical study of electrical biomolecule enrichment in microfluidics

Multi-physical study of electrical biomolecule enrichment in microfluidics

Research & development - Leuven | More than two weeks ago

Exploring new micro/nanofluidic technology for future life science applications

The ability to precisely manipulate biomolecules at the microscale can radically enhance the utility and function of current microfluidic technologies. One of the most promising techniques to do so is dielectrophoresis (DEP). Activated by applying non-uniform electric field through micro-fabricated electrodes, it can selectively confine biomolecules in localised regions of a microfluidic system. However, current implementations of dielectrophoresis in microfluidic devices are complicated by additional multi-physics phenomena, such as the Brownian motion, electrothermal flow and electroosmotic flow.

 

In this thesis, we will investigate the multi-physical effects associated with dielectrophoresis and their impact on the biomolecule enrichment. The models will be based on established theory or those reported in the literature. Preferably, we will validate the model results by available experimental data. Finally, we will apply the developed multi-physics model for design optimizations towards high-efficiency electrical biomolecule manipulations.

 

This thesis will primarily consist of modelling after literature study. Typical education background includes physics, electrical engineering, mechanical engineering, biomedical engineering and chemical engineering.



Type of project: Thesis, Internship

Duration: 1 year

Required degree: Master of Engineering Science, Master of Engineering Technology

Required background: Chemistry/Chemical Engineering, Biomedical engineering, Electrotechnics/Electrical Engineering, Nanoscience & Nanotechnology, Physics

Supervising scientist(s): For further information or for application, please contact: Ying Ting Set (Ying.Ting.Set@imec.be)