/Photonic and biological characterization of an on-chip waveguide biosensor

Photonic and biological characterization of an on-chip waveguide biosensor

Leuven | More than two weeks ago

Take your first steps into the world of photonics

Imec has developed an on-chip waveguide-based biosensor technology that is capable of measuring the presence of proteins in biological samples in just a matter of minutes. We have recently created a new design which, in theory, can filter out excitation light from fluorescence at the chip level. This is an improvement over the current design where the excitation light is removed from fluorescence using an interference filter. The improved design allows to measure both fluorescence and excitation power simultaneously, allowing for active correction of the measured data while also reducing the complexity of the measurement setup. The chips incorporating this improved design have been fabricated and we would like you to

  • Study the experimental performance of the on-chip fluorescence filters and compare the results against simulations.
  • Perform fluorescence immunoassays on the chip and measure sensitivity.
  • Create an analysis program that can correct the measured fluorescence signal based on changes in the measured excitation light.


For this work, you will be working on waveguide chips that have been fabricated in imec’s state of the art cleanroom. You will gain a theoretical understanding of photonic waveguide technology and its applications in the field of biosensing. Additionally, you will learn to perform optical characterization experiments and compare the experimental performance of these chips against simulations performed using Lumerical FDTD (Finite Difference Time Domain). Finally, you will also learn to perform immunoassays on waveguides and analyze the data generated using a matlab or python program.

Type of project: Combination of internship and thesis

Duration: 6 months to 1 year

Required degree: Master of Engineering Science, Master of Science

Required background: Nanoscience & Nanotechnology

Supervising scientist(s): For further information or for application, please contact: Finub James Shirley (Finub.JamesShirley@imec.be)

Imec allowance will be provided for students studying at a non-Belgian university.