/Single cell integrative analysis by high density CMOS MEA chips

Single cell integrative analysis by high density CMOS MEA chips

Master projects/internships - Leuven | More than two weeks ago

Push the boundaries of investigating cellular networks at single cell level using integrative analysis techniques powered by imec's high-density MEA platform

Imec's high-density microelectrode array (HD-MEA) platform is a powerful instrument to study cellular networks at single cell resolution. With more than 16k electrodes and an electrode pitch of 15um, the chip enables to study cellular processes at unprecedented level. This platform features several modalities such as electrical stimulation, electroporation, electrophysiological recording, impedance spectroscopy to study a variety of cell types and assays.
In this thesis/internship, novel approaches will be investigated that further expand the chips' capabilities. We will investigate current/voltage clamping of single cells for intracellular recording and combine inducing of cell differentiation  with spatial transcriptomics. 
A background in electrophysiology/MEA and/or spatial transcriptomics is recommended. 

Type of project: Internship; Thesis; Combination of internship and thesis

Master's degree: Master of Engineering Science; Master of Science; Master of Bioengineering

Duration: minimum 6 months 

Master program: Biomedical engineering; Nanoscience & Nanotechnology; Physics; Bioscience Engineering

Supervising scientists: For further information or for application, please contact Dries Braeken (dries.braeken@imec.be) and Carolina Mora Lopez (Carolina.MoraLopez@imec.be).

Imec allowance will be provided for students studying at a non-Belgian university