Structured illumination microscopy in 2D

Leuven - PhD
|
More than two weeks ago

You will make significant contributions to the development of a completely new way of doing fluoresence microscopy and be part of a team working on a prestigious ERC starting grant.

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Fluorescent microscopy is an indispensable tool in biology and medicine that has fueled many breakthroughs in a wide set of sub-domains.Recently the world of microscopy has witnessed a true revolution in terms of increased resolution of fluorescent imaging techniques, even resulting a Nobel Prize in 2014. High resolution microscopy is also responsible for the spectacular cost reduction of DNA sequencing during the last decade. ​

The next big push in microscopy with a large societal impact will come from extremely compact and robust optical systems that will make high-resolution (fluorescence) microscopy highly accessible, enabling both cellular diagnostics at the point of care and the development of compact, cost-effective DNA sequencing instruments, facilitating early diagnosis of cancer and other genomic disorders. 

Imec is developing a novel high-resolution imaging platform, based on a only a single chip, that will completely eliminate the necessity of standard free-space optical components. This new concept will provide imaging beyond the resolution limit set by the sensor pixel size and the point spread function of an extremely compact microscopy system.

This PhD topic will target two main challenges:

  • Development of algorithms for calculating optimal holograms targeted to the generation of specific two dimensional structured light fields.
  • ​​Development of image reconstruction algorithms dedicated to super-resolution microscopy using the afore-mentioned structured light fields. ​

The results will have immediate impact on the development of the new on-chip fluorescence microscopy platform. The results will be implemented in real devices and experimentally verified. The candidate will be strongly embedded in the biophotonics team, working closely together with photonics designers and experimentalists.
Furthermore, this PhD topic is part of a prestigious ERC starting grant project funded by the European Research Counsel.​

A good candidate has:
  • A strong mathematical background
  • Experience with coding (Python, Matlab)
  • A background in structured illumination microscopy, super resolution microscopy, and/or holography
  • Good notions of wave propagation and interference, photonics, optics, (fluorescence) microscopy

Required background: Physics, mathematics, electrical engineering, computer science or equivalent

Type of work: 60% modeling & simulation, 30% theory, 20% literature

Supervisor: Pol Van Dorpe, Niels Verellen

Daily advisor: Niels Verellen

The reference code for this position is 1812-52. Mention this reference code on your application form.

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