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/Job opportunities/Wavefront shaping using integrated photonics for deep tissue imaging

Wavefront shaping using integrated photonics for deep tissue imaging

PhD - Leuven | More than two weeks ago

You will enable a leap in imaging in living tissue by developing the next generation integrated photonic technology for high speed, high density phase control, resulting in sub cellular resolution at previously unattainable depths

Biomedical imaging is a cornerstone of scientific discovery, which provides the basis for the development of novel therapies and pharmacological treatments. However, our understanding of the complex cellular processes inside living systems remains fragmented, since structural and/or functional imaging of complete, intact living objects remains challenging with microscopy techniques today. Current approaches especially fail to sustain this sub-cellular resolution in-vivo at elevated depths due to the strong scattering of light in tissue, which poses a major limitation for imaging large volumes at high resolution. 

Recent advances in bio-photonics and imaging techniques promise to deliver deeper penetration at high resolution by actively compensating for tissue scattering. However, the adoption of these tools in biomedical applications has been lagging, in part because key technologies, such as the available spatial light modulators, show limited performance. 

 

In this PhD project, you will address the above challenges by developing powerful photonic integrated circuit (PIC) chips, which can project custom light patterns at high speed. This work builds on existing approaches at imec around optical beam forming. The new PICs provide the basis for advancing in-vivo two-photon microscopy by introducing high speed scattering compensation. The PhD project will be embedded in an international collaboration with specialists in scattering compensation microscopy, allowing you to be immersed in the existing techniques. Subsequent co-design of the PICs and the microscope around the chip will allow better system-level tradeoffs. The technique will be initially validated on phantoms, and finally on in-vitro and in-vivo tissue in collaboration with biology-experts.

Imec is soliciting enthusiastic PhD candidates to advance imaging through turbid media, focusing both on photonic chip design and on the microscopy challenges using the photonic chips.



Required background: Electrical Engineering/Photonics/Optics/Physics

Type of work: 40% design & simulation, 45% Experimental, 15% Literature

Supervisor: Pol Van Dorpe

Co-supervisor: Xavier Rottenberg

Daily advisor: Roelof Jansen, Niels Verellen

The reference code for this position is 2021-088. Mention this reference code on your application form.

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