Sensor and microfluidics integration for dynamic, scalable organs-on-chip

Leuven - PhD
|
Meer dan twee weken geleden

Development of advanced microfluidic devices for emulating the human physiology on chip

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The intestine is a major organ and plays a central role in transport of drugs and nutrients, and in the body’s immune response. Besides pharmacokinetics, also inflammatory diseases and the role of the microbiome are critical research areas in health and disease. Nevertheless, there is a pressing shortage of well-established human gut models for drug development and screening. Organ-on-chip systems such as the gut-on-chip aim to fill this gap as they can mimic the complex multi-compartment, multi-cellular environment of the intestine, as well as the flow and molecule transport to and from cells. In this project, we will integrate sensor platforms with microfluidics to enable flow transport and mechanical strain/stretch. We will investigate barrier function of complex multi-cellular tissues to study integrity and cell-cell interactions.

Required background: Biotechnology, bioengineering

Type of work: 20% modelin, 10% literature, 70% experimental

Supervisor: Liesbet Lagae, Dries Braeken

Daily advisor: Dries Braeken

The reference code for this position is 1812-49. Mention this reference code on your application form.

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