Transport of nanoparticles in biological tissues

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Learn how to model nanoparticle transport

Biological tissues can be considered as porous media exhibiting features of anomalous diffusion. The anomalous transport come into play when a nano-object, such as virus or a nanoparticle, diffuses in the tissue and is characterized by power law displacement instead of linear one. On the other hand, popular approaches in literature assume linear diffusion models, which may overestimate certain accumulation effects. Obtained results can be further used to improve the understanding of drug delivery of nanoparticles and viral vectors.
This objective of the project will be to investigate diffusion in a biologically-relevant complex medium, representing a tissue phantom. The diffusion profiles will used to determine whether material transport occurs and whether the obtained diffusion profiles follow Fick’s laws or are anomalous. As a second line of investigation, an experiment with nanoparticle tracking will be prepared.
The student will get familiar with the literature on anomalous transport and nanoparticles delivery/ viral vectors. The student will acquire images on a laboratory confocal microscope and will fit the observed intensity profiles to models published in the literature.


The candidate

Required skills: Experience with basic biochemistry and confocal microscopy
Desired skills: experience with data analysis

Type of project: Combination of internship and thesis

Duration: 6 -9 months

Required degree: Master of Bioengineering, Master of Science

Required background: Biomedical engineering, Bioscience Engineering, Physics, Nanoscience & Nanotechnology

Supervising scientist(s): For further information or for application, please contact: Dimiter Prodanov (Dimiter.Prodanov@imec.be)

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