Postdoctoral Researcher on DNA Synthesis using CMOS Addressable Electrodes
What you will do
Conventional microarrays using in-house spotting technologies to deposit cDNA fragments have been largely replaced by commercial high-density oligonucleotide-arrays. For their production, the sites of interest are optically addressed to allow for in-situ DNA synthesis. Here, instead of using optical methods, we propose the use of electrically induced reactions to develop a DNA array with an unpreceded resolution. In other words, by sequentially adding nucleotides and applying a potential to individually addressable electrode sites to induce a coupling reaction, nucleotides can be incorporated on predefined locations.
Although electrically induced coupling can be used for various site-selective coupling strategies, we aim to make a high-density oligonucleotide array for select biological applications. One major application, in collaboration with the KTH Royal Institute of Technology in Sweden, focuses on the digitization of pathological analysis by linking pheno- to genotypes using DNA arrays in combination with sequence analysis. In other words, the proposed project takes advantage of both CMOS scaling and the recent boost in next-generation sequencing technologies to enable truly innovative, high-end biological applications.
In this position, you will:
- Optimize design of experiments, independently performs tests in the lab, and interpret results;
- Construct, modify, calibrate, operate and set up equipment used for performing your experimental work;
- Collect, analyze and report scientific data leading to valid conclusions and keep abreast of cutting-edge methodology in the areas of electrical DNA synthesis on chip.
What we do for you
We offer you the opportunity to join one of the world’s premier research centers in nanotechnology at its headquarters in Leuven, Belgium. With your talent, passion and expertise, you’ll become part of a team that makes the impossible possible. Together, we shape the technology that will determine the society of tomorrow.
We are proud of our open, multicultural, and informal working environment with ample possibilities to take initiative and show responsibility. We commit to supporting and guiding you in this process; not only with words but also with tangible actions. Through imec.academy, 'our corporate university', we actively invest in your development to further your technical and personal growth.
We are aware that your valuable contribution makes imec a top player in its field. Your energy and commitment are therefore appreciated by means of a competitive salary.
Who you are
- You have a PhD degree in (bio)engineering or electrochemistry.
- We value your hands-on personality with excellent engineering skills and a personal drive to achieve project goals.
- You are driven to work in a research lab environment and have a special interest in technology.
- We appreciate your experience in electrochemistry and electrochemical techniques. Ideally, you also optimized and designed assays yourself.
- Prior experience in DNA synthesis or diffusion modelling and expertise in microfabrication in a cleanroom environment are considered an asset.
- You have a good overview of diagnostic techniques and methodologies.
- We are looking for your excellent communication and team player skills as you will work in a multidisciplinary and multicultural team of imec researchers, PhD students and industrial researchers.
- Given the international character of imec, excellent knowledge of English is a must.