CMOS and beyond CMOS
Discover why imec is the premier nanoelectronics R&D center in the development of industry-relevant solutions for advanced logic & memory devices.
Connected health solutions
Explore the technologies that will power tomorrow’s wearable, implantable, ingestible and non-contact devices.
Life sciences
As a pioneer in nanoelectronics, imec brings the power of chip technology to the world of healthcare.
Sensor solutions for IoT
Imec develops innovative solutions for sensor networks, high speed networks and sensor technologies for the Internet of Things.
Artificial intelligence
Artificial intelligence is no longer the stuff of science fiction: its technologies are ready and its possibilities are real. It’s time to explore them, and imec is ready to help you.
More expertises
Discover all our expertises.
Research
Be the first to reap the benefits of imec’s research by joining one of our programs or starting an exclusive bilateral collaboration.
Development
Build on our expertise for the design, prototyping and low-volume manufacturing of your innovative nanotech components and products.
Solutions
Use one of imec’s mature technologies for groundbreaking applications across a multitude of industries such as healthcare, agriculture and Industry 4.0.
Venturing and startups
Kick-start your business.Launch or expand your tech company by drawing on the funds and knowhow of imec’s ecosystem of tailored venturing support.

Whitepaper cell therapy

Raising the bar in manufacturing cell therapy products

Nanoelectronics driving accuracy, improving turnaround times and increasing yields in cell therapy workflows

Introduction

The field of cell therapy reached a major milestone the past year with the first CAR T products getting FDA approval: USD Kymriah of Novartis and Yescarta of Kite Pharma. It is likely that this is just the beginning of a wave of T-cell immunotherapy success stories. Now, the focus has turned to clinical adoption and that requires the manufacturing process to be more efficient, upscalable and standardized in order to achieve a safe and efficacious therapy for numerous patients. The fact that the adoptive therapy consists of live cells, manufactured from T cells derived from the individual patient, represents major challenges for the process development. Today, this has resulted in a long production time (3 weeks to 3 months), high costs and – due to manual intervention at different stages in the process flow – a risk for contamination.

This whitepaper describes some unique results that clearly demonstrate how nanoelectronic sensors can contribute to a standardized, cost-effective and fully automated cell therapy process flow.

What you will learn

  • How novel developments in nanoelectronics and silicon technology enable the development of fully integrated sensor solutions combining microfluidics, photonics-based biosensors, single-cell manipulation, lens-free on-chip microscopy etc.
  • How these technologies can be combined and integrated to drastically upscale and reduce the production cost and turnaround time of (CAR T) cell therapy process flow
  • How these technologies can be used to automate cellular analysis and to measure cell number, cell viability, cell morphology, growth medium parameters and cell products for improving the efficacy of cell therapies.
  • How such an integrated and automated approach can significantly improve the cell therapy workflow both in terms of ease of use, reliability and reproducibility and scalability.

Download

To read the full whitepaper, please complete the form

This content is only visible on the desktop version of this website.

!-->