3D focused on-chip cell sorting for rare cell recovery – Experimental investigation and technology development

Imec is a global leader in semiconductor innovation and microfabrication technologies. Within an interdisciplinary team, we explore how microchips can transform biomedical research and diagnostics. This internship centers on the development and evaluation of on-chip cell sorters aimed at isolating rare cells directly from blood samples. These cells are often extremely scarce, requiring technologies that combine exceptional recovery rates with gentle handling to preserve biological integrity. In this chip generation, three-dimensional hydrodynamic focusing is integrated, which allows more precise sample alignment and improved sorting efficiency. As part of the project, the candidate will investigate the technical performance and reliability of the device, examine aspects such as fluidic stability and device lifetime, while also assessing target sample purity and recovery yield.

This internship also offers a purely hands-on opportunity to work at the interface of microfluidics, optics, and biomedicine, providing a comprehensive understanding of how advanced the sorting platform can be engineered for diagnostic applications.

Candidate profile:

• Hands-on experience in microfluidics, optics, biological instruments, and system engineering are highly preferred.
• Analytical mindset with good data interpretation and reporting skills; ability to work independently in a research laboratory is highly valued.
• Strong motivation to contribute within an interdisciplinary research environment.

Objectives/Main Tasks:

• Design and conduct a series of tests to evaluate the performance of the cell-sorting chip
• Investigate device robustness, including heater endurance during extended operation.
• Analyze the stability and effect of 3D hydrodynamic focusing
• Collaborate with engineers and biologists to correlate technological parameters with biological outcomes such as post-sort cell viability.
• Document findings and support result dissemination through internal reports
   

Master's degree: Master of Science, Master of Engineering Technology, Master of Engineering Science, Master of Bioengineering

Required educational background: Biomedical engineering, Nanoscience & Nanotechnology, Physics, Bioscience Engineering

Duration: 6-8 months

For more information or application, please contact the supervising scientists Sarah Libbrecht (Sarah.Libbrecht@imec.be) and Radin Tahvildari (Radin.Tahvildari@imec.be).