Investigation of microfabricated brain catheters for drug delivery

Leuven - Master projects
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Ongeveer een week geleden

Micro-scale 3D printing is an invaluable tool for fast prototyping of microfluidic components and it could lead to a new generation of medical devices for drug administration.

Convection-enhanced delivery (CED) is a technique that is used in neuroscience and as a clinical strategy in the advanced stages of neuro-oncological treatment. The adoption of this technique could have a huge impact on the diagnosis of high-grade gliomas and it could open the door to a new course of drug development studies. This technique, however, is currently held back by the lack of suitable technology that allows a quick and localised fluid delivery. In this context, a modern microfabrication technique known as two-photon polymerisation (TPP) could be the key to unlock the hidden potential of CED in neuroscience and neuro-oncology. TPP allows the creation of complex three-dimensional structures and it can be repurposed to manufacture a state-of-the-art medical device for fluidic interfacing with the brain. The student will have the opportunity to experience different aspects of the project, including rapid prototyping, experimental design and data analysis. The candidate will also benefit from working in a highly motivating environment with cutting-edge technology and state-of-the-art laboratory and cleanroom settings. This experience will help gain an insight into this challenging new field and its opportunities.


Type of project: Thesis

Required degree: Master of Engineering Technology, Master of Science, Master of Engineering Science

Required background: Biomedical engineering, Electromechanical engineering, Electrotechnics/Electrical Engineering, Mechanical Engineering

Supervising scientist(s): For further information or for application, please contact: Simone Marcigaglia (Simone.Marcigaglia@nerf.be)

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