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DNA hybridization detection with EGFETs
PhD internship - Leuven | Just now
Explore DNA hybridization detection with Extended-Gate FETs for a fully-integrated real-time biosensing platform
Liquid-gated extended-gate Field-Effect Transistors (EGFETs) leverage the robustness and scalability of commercial CMOS technology while enabling direct interaction with (bio)chemical environments using an exposed electrode which is connected to the FET's gate. By post-processing commercial CMOS wafers we fabricated EGFET chips with varying EGFET dimensions. This internship focuses on the advanced electrical and electrochemical characterization of these liquid‑gated EGFET sensors, aiming to evaluate their potential as fully integrated biosensing platforms. More specifically, the detection of DNA hybridization will be explored and the impact of different surface functionalization procedures on the sensitivity will be evaluated. During this project the student will electrically characterize the standard liquid‑gated FET IdVg characteristics, sensor stability and hybridization sensitivity across varying electrolyte conditions and surface functionalization protocols. The electrical measurements will be executed on a probe station while a microfluidic setup enables the automated exchange between different electrolyte conditions. Benchmarks include dose-response curves, drift, hysteresis, and noise characteristics. The project results will contribute to the development of a fully-integrated real-time biosensing platform.
Type of internship: PhD internship
Duration: 6 months
Required educational background: Chemistry/Chemical Engineering, Bioscience Engineering, Electrotechnics/Electrical Engineering, Nanoscience & Nanotechnology, Materials Engineering
University promotor: Pol Van Dorpe (KU Leuven)
Supervising scientist(s): For further information or for application, please contact Sybren Santermans (Sybren.Santermans@imec.be) and Koen Martens (Koen.Martens@imec.be)
The reference code for this position is 2026-INT-142. Mention this reference code in your application.
Imec allowance will be provided for students studying at a non-Belgian university.
Applications should include the following information:
- resume
- motivation
- current study
Incomplete applications will not be considered.