Multiplexed perfusable 3D vascular networks on-chip as bio-docking platform for scalable organoid cultivation

We are inviting applications for a PhD position in an exciting interdisciplinary research project focused on the development of multiplexed, perfusable 3D vascular networks on-chip as a next-generation bio-docking platform for scalable organoid cultivation. This project addresses a critical bottleneck in organoid technology – namely, the lack of vascularization – which limits organoid size, maturation, and physiological relevance. By engineering microfluidic systems that mimic native vascular networks, we aim to create perfusable environments that support long-term viability, functional integration, and dynamic nutrient exchange for organoids.

In addition to advancing organoid culture, the candidate will investigate how vascularization influences brain tumor progression and drug response, using patient-derived glioblastoma tumoroid models. This dual focus offers a unique opportunity to contribute to both fundamental bioengineering and translational cancer research.

The candidate will work at the intersection of microfluidics, tissue engineering, stem cell biology, and brain tumor biology, contributing to the design and fabrication of vascularized chips, integration of organoid and tumoroid models, and development of perfusion and stimulation protocols. The project builds on validated microfluidic chip prototypes connected to perfusion systems, which will serve as the foundation for further innovation.

We are seeking a highly motivated student with a strong interest in bioengineering, microfabrication, 3D cell culture, cancer biology, and drug discovery. Prior experience with stem cell-derived organoids or tumoroids, biomaterials, or microfluidic device development is advantageous but not required. The candidate will receive comprehensive training in advanced cell culture techniques, molecular biology assays, imaging, chip-based system integration, and microfluidic fabrication. They will also benefit from access to imec’s world-class infrastructure and collaborative research ecosystem, working alongside experts in engineering, biology, and translational medicine.

This position offers a unique opportunity to contribute to high-impact biomedical innovation and develop a future-ready skillset in organ-on-chip technologies, with opportunities to publish, present, and collaborate across disciplines.