Leuven | More than two weeks ago
Explore biosensing at the nanoscale
The target molecule’s properties, such as its charge, shape, hydrophilicity, etc. play a crucial role in sensing. Synthetic molecules can be designed to probe for the impact of different properties. Moreover, the surface of the transistor sensor plays an important role in FET-based biosensing. Coatings such as Self-Assembled Monolayers (SAM), Poly-Ethylene Glycol (PEG) coatings, Atomic Layer Deposition (ALD) coatings can have a strong impact on the sensor’s signal strength. For the bioFET case, the sensor needs to be functionalized with special molecules that can bind specifically with the target biomolecules floating around in the electrolyte solution. For the nanopore FET, coatings strongly impact the electroosmotic flow through the nanopore. In both cases, surface charge is a key parameter that determines signal strength and which can be tailored with coatings.
During the master thesis, these FET sensors will be characterized in detail to understand their behavior for different types of target molecules and/or for different types and methods of surface coatings. Work can also be done on analyzing the noise contribution of the coatings, molecules and the effect of the electrolytic environment. The thesis will involve working in the cleanroom, bio-chemistry labs and on electrical characterization tools. Molecular sensitivity and the potential of obtaining FET-based molecular sensors will be investigated.
Type of project: Combination of internship and thesis, Thesis, Internship
Duration: minimum 3 months
Required degree: Master of Engineering Science, Master of Science, Master of Bioengineering
Required background: Bioscience Engineering, Chemistry/Chemical Engineering, Nanoscience & Nanotechnology, Physics, Electrotechnics/Electrical Engineering