Advancing bio-nanoparticle sampling

Lipid nanoparticles (LNPs) are at the heart of modern drug delivery systems, including mRNA-based vaccines and targeted cancer therapies. Their ability to encapsulate and protect fragile molecules makes them essential for precision medicine. However, current LNP manufacturing methods face a critical limitation: the lack of real-time, inline quality control. This gap can lead to variability in particle size, composition, and stability. By leveraging semiconductor-based sensing and control technologies, we aim to overcome this challenge and enable scalable, high-precision manufacturing of advanced therapeutics. By joining this project, you will contribute to research that directly impacts drug delivery innovation and cancer research breakthroughs.

Project overview
The primary objective of this research is focused on developing next-generation sampling technologies for bio-nanoparticles. This platform aims to enable precise, composition-based sampling of particles such as mRNA lipid nanoparticles, critical components in advanced therapeutics and biologics manufacturing. By integrating cutting-edge sensor technology and robust design principles, the aim is to transform inline quality control and accelerate innovation in healthcare.

Scope of work
During the internship, the student will conduct experimental studies including:

• Feasibility studies: Validate selective sampling for biologically relevant nanoparticles.
• Robustness testing: Explore performance under challenging conditions, including high ionic strength and protein contamination.
• Device optimization: Support experiments on electrode configurations
• Data analysis & reporting: Document findings and assist in preliminary analysis to guide future development.

Candidate profile
Prospective candidates should have a keen interest in hands-on experimental work. Ambition to learn and willingness to develop new skills are critical.

Why join?
This internship offers hands-on experience in microelectronics-driven life sciences, combining experimental work with real-world impact. Interns will collaborate with imec experts, gain exposure to state-of-the-art lab facilities in an international environment and contribute to a project that bridges semiconductor technology and biopharma innovation.
 

Type of Project: Internship

Master's degree: Master of Science; Master of Bioengineering; Master of Engineering Science

Duration:  6-12 months

For more information or application, please contact the supervising scientist Naghmeh Fatemi (naghmeh.fatemi@imec.be).